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Target
Dual specificity mitogen-activated protein kinase kinase 7
Ligand
BDBM50577671
Substrate
n/a
Meas. Tech.
ChEMBL_2130726 (CHEMBL4840155)
IC50
840±n/a nM
Citation
 Kwong, AJ; Pham, TND; Oelschlager, HE; Munshi, HG; Scheidt, KA Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma. ACS Med Chem Lett 12:1559-1567 (2021) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 7
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4
Type:
Protein
Mol. Mass.:
47502.52
Organism:
Homo sapiens (Human)
Description:
O14733
Residue:
419
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
  
Inhibitor
Name:
BDBM50577671
Synonyms:
CHEMBL4872723
Type:
Small organic molecule
Emp. Form.:
C19H14FN3O2S
Mol. Mass.:
367.397
SMILES:
Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)Nc1ccccc1
Structure:
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