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Target
Stimulator of interferon genes protein
Ligand
BDBM50581796
Substrate
n/a
Meas. Tech.
ChEMBL_2152290 (CHEMBL5036837)
EC50
7.0±n/a nM
Citation
 Pimková Polidarová, M; B?ehová, P; Kaiser, MM; Smola, M; Dra?ínský, M; Smith, J; Marek, A; Dejmek, M; ?ála, M; Gutten, O; Rulí?ek, L; Novotná, B; Brázdová, A; Janeba, Z; Nencka, R; Boura, E; Páv, O; Birku?, G Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP). J Med Chem 64:7596-7616 (2021) [PubMed]  Article 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50581796
Synonyms:
CHEMBL5078036
Type:
Small organic molecule
Emp. Form.:
C20H22F2N10O9P2S
Mol. Mass.:
678.46
SMILES:
[H][C@@]12COP(O)(=O)O[C@@]3([H])[C@@H](F)[C@@H](O[C@]3([H])CO[P@@](S)(=O)O[C@@]1([H])[C@@H](F)[C@@H](O2)n1cnc2c(N)ncnc12)n1cnc2c(N)ncnc12 |r|
Structure:
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