Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein
Ligand
BDBM50581800
Substrate
n/a
Meas. Tech.
ChEMBL_2152297 (CHEMBL5036844)
EC50
20±n/a nM
Citation
Pimková Polidarová, M; B?ehová, P; Kaiser, MM; Smola, M; Dra?ínský, M; Smith, J; Marek, A; Dejmek, M; ?ála, M; Gutten, O; Rulí?ek, L; Novotná, B; Brázdová, A; Janeba, Z; Nencka, R; Boura, E; Páv, O; Birku?, G Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP). J Med Chem 64:7596-7616 (2021) [PubMed] Article
More Info.:
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
Inhibitor
Name:
BDBM50581800
Synonyms:
CHEMBL5073386
Type:
Small organic molecule
Emp. Form.:
C32H42F2N10O14P2
Mol. Mass.:
890.6788
SMILES:
[H][C@@]12CO[P@@](=O)(OCOC(=O)C(C)(C)C)O[C@@]3([H])[C@@H](F)[C@@H](O[C@]3([H])CO[P@@](=O)(OCOC(=O)C(C)(C)C)O[C@@]1([H])[C@@H](F)[C@@H](O2)n1cnc2c(N)ncnc12)n1cnc2c(N)ncnc12 |r|