Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50150414
Substrate
n/a
Meas. Tech.
ChEMBL_302553 (CHEMBL828254)
Ki
23±n/a nM
Citation
 Mattson, RJ; Denhart, DJ; Catt, JD; Dee, MF; Deskus, JA; Ditta, JL; Epperson, J; Dalton King, H; Gao, A; Poss, MA; Purandare, A; Tortolani, D; Zhao, Y; Yang, H; Yeola, S; Palmer, J; Torrente, J; Stark, A; Johnson, G Aminotriazine 5-HT7 antagonists. Bioorg Med Chem Lett 14:4245-8 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50150414
Synonyms:
CHEMBL182840 | N,N-Dimethyl-N''-(2-phenoxy-ethyl)-N''''-((S)-1-phenyl-ethyl)-[1,3,5]triazine-2,4,6-triamine
Type:
Small organic molecule
Emp. Form.:
C21H26N6O
Mol. Mass.:
378.4707
SMILES:
C[C@H](Nc1nc(NCCOc2ccccc2)nc(n1)N(C)C)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: