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Target
Stimulator of interferon genes protein
Ligand
BDBM50509050
Substrate
n/a
Meas. Tech.
ChEMBL_2160789 (CHEMBL5045539)
EC50
11±n/a nM
Citation
 Cherney, EC; Zhang, L; Lo, J; Huynh, T; Wei, D; Ahuja, V; Quesnelle, C; Schieven, GL; Futran, A; Locke, GA; Lin, Z; Monereau, L; Chaudhry, C; Blum, J; Li, S; Fereshteh, M; Li-Wang, B; Gangwar, S; Pan, C; Chong, C; Zhu, X; Posy, SL; Sack, JS; Zhang, P; Ruzanov, M; Harner, M; Akhtar, F; Schroeder, GM; Vite, G; Fink, B Discovery of Non-Nucleotide Small-Molecule STING Agonists  J Med Chem 65:3518-3538 (2022) [PubMed]  Article 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50509050
Synonyms:
CHEMBL4438309
Type:
Small organic molecule
Emp. Form.:
C42H51N13O7
Mol. Mass.:
849.9372
SMILES:
CCn1nc(C)cc1C(=O)\N=c1/[nH]c2cc(cc(OC)c2n1C\C=C\Cn1c2c(OCCCN3CCOCC3)cc(cc2[nH]\c1=N/C(=O)c1cc(C)nn1CC)C(N)=O)C(N)=O
Structure:
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