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Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM50584973
Substrate
n/a
Meas. Tech.
ChEMBL_2160978 (CHEMBL5045728)
IC50
4.6±n/a nM
Citation
 Tong, L; Wang, P; Li, X; Dong, X; Hu, X; Wang, C; Liu, T; Li, J; Zhou, Y Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. J Med Chem 65:3229-3248 (2022) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM50584973
Synonyms:
CHEMBL5069893
Type:
Small organic molecule
Emp. Form.:
C21H25F3N6O
Mol. Mass.:
434.458
SMILES:
N[C@H]1CC[C@H](CC1)Nc1nc(Nc2ccc(NC(=O)C3CC3)cc2)ncc1C(F)(F)F |r,wU:4.7,1.0,(28.21,-29.89,;26.87,-30.66,;26.87,-32.2,;25.54,-32.96,;24.21,-32.19,;24.2,-30.66,;25.54,-29.88,;22.88,-32.97,;22.88,-34.51,;24.22,-35.27,;24.22,-36.82,;25.56,-37.59,;26.89,-36.82,;28.22,-37.59,;29.55,-36.82,;29.55,-35.27,;30.88,-34.5,;32.22,-35.27,;32.22,-36.81,;33.55,-34.49,;35.08,-34.48,;34.31,-33.15,;28.21,-34.51,;26.88,-35.28,;22.89,-37.59,;21.55,-36.82,;21.55,-35.28,;20.22,-34.51,;20.22,-32.97,;18.89,-35.28,;18.88,-33.74,)|
Structure:
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