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Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM50584979
Substrate
n/a
Meas. Tech.
ChEMBL_2160978 (CHEMBL5045728)
IC50
4.0±n/a nM
Citation
 Tong, L; Wang, P; Li, X; Dong, X; Hu, X; Wang, C; Liu, T; Li, J; Zhou, Y Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. J Med Chem 65:3229-3248 (2022) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM50584979
Synonyms:
CHEMBL5086374
Type:
Small organic molecule
Emp. Form.:
C19H21F3N6O
Mol. Mass.:
406.4048
SMILES:
N[C@H]1CC[C@H](CC1)Nc1nc(Nc2ccc3C(=O)NCc3c2)ncc1C(F)(F)F |r,wU:4.7,1.0,(63.22,-43.97,;61.88,-44.74,;61.88,-46.28,;60.55,-47.05,;59.22,-46.28,;59.21,-44.74,;60.55,-43.97,;57.89,-47.06,;57.89,-48.6,;59.23,-49.36,;59.23,-50.91,;60.57,-51.68,;61.9,-50.91,;61.89,-49.37,;63.22,-48.6,;64.56,-49.36,;66.02,-48.88,;66.49,-47.41,;66.93,-50.12,;66.03,-51.37,;64.57,-50.9,;63.23,-51.68,;57.89,-51.69,;56.56,-50.91,;56.56,-49.37,;55.23,-48.6,;55.23,-47.06,;53.89,-49.37,;53.89,-47.83,)|
Structure:
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