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Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM50584955
Substrate
n/a
Meas. Tech.
ChEMBL_2160979 (CHEMBL5045729)
IC50
14±n/a nM
Citation
 Tong, L; Wang, P; Li, X; Dong, X; Hu, X; Wang, C; Liu, T; Li, J; Zhou, Y Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. J Med Chem 65:3229-3248 (2022) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM50584955
Synonyms:
CHEMBL5075715
Type:
Small organic molecule
Emp. Form.:
C17H20F3N7O
Mol. Mass.:
395.3822
SMILES:
N[C@H]1CC[C@H](CC1)Nc1nc(Nc2ccc(nc2)C(N)=O)ncc1C(F)(F)F |r,wU:4.7,1.0,(28.57,-3.26,;27.24,-4.02,;27.24,-5.57,;25.91,-6.33,;24.58,-5.56,;24.57,-4.02,;25.9,-3.25,;23.25,-6.34,;23.25,-7.88,;24.59,-8.64,;24.59,-10.19,;25.93,-10.96,;27.26,-10.19,;27.25,-8.65,;28.57,-7.88,;29.92,-8.64,;29.92,-10.19,;28.59,-10.96,;31.25,-7.87,;32.59,-8.64,;31.24,-6.33,;23.25,-10.96,;21.92,-10.19,;21.92,-8.65,;20.59,-7.88,;20.59,-6.34,;19.25,-8.65,;19.25,-7.11,)|
Structure:
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