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Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM50584967
Substrate
n/a
Meas. Tech.
ChEMBL_2160979 (CHEMBL5045729)
IC50
7.4±n/a nM
Citation
 Tong, L; Wang, P; Li, X; Dong, X; Hu, X; Wang, C; Liu, T; Li, J; Zhou, Y Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. J Med Chem 65:3229-3248 (2022) [PubMed]  Article 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM50584967
Synonyms:
CHEMBL5085950
Type:
Small organic molecule
Emp. Form.:
C18H20F3N5O2
Mol. Mass.:
395.3789
SMILES:
NC(=O)c1ccc(Nc2ncc(c(N[C@H]3CC[C@H](O)CC3)n2)C(F)(F)F)cc1 |r,wU:14.13,wD:17.17,(83.29,-9.2,;81.96,-8.43,;81.95,-6.89,;80.63,-9.21,;80.63,-10.75,;79.3,-11.52,;77.97,-10.75,;76.63,-11.52,;75.3,-10.76,;73.96,-11.53,;72.63,-10.76,;72.63,-9.21,;73.96,-8.44,;73.95,-6.9,;75.29,-6.13,;75.27,-4.59,;76.61,-3.82,;77.95,-4.59,;79.28,-3.82,;77.95,-6.13,;76.62,-6.9,;75.29,-9.21,;71.3,-8.44,;71.3,-6.9,;69.96,-9.21,;69.96,-7.67,;77.96,-9.22,;79.28,-8.44,)|
Structure:
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