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Target
D(4) dopamine receptor
Ligand
BDBM50585101
Substrate
n/a
Meas. Tech.
ChEMBL_2161628 (CHEMBL5046489)
Ki
26±n/a nM
Citation
 Bonifazi, A; Battiti, FO; Sanchez, J; Zaidi, SA; Bow, E; Makarova, M; Cao, J; Shaik, AB; Sulima, A; Rice, KC; Katritch, V; Canals, M; Lane, JR; Newman, AH Novel Dual-Target ?-Opioid Receptor and Dopamine D J Med Chem 64:7778-7808 (2021) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50585101
Synonyms:
CHEMBL5089655
Type:
Small organic molecule
Emp. Form.:
C30H34Cl2N4
Mol. Mass.:
521.524
SMILES:
Clc1cccc(N2CCN(CCCCNCCC(C#N)(c3ccccc3)c3ccccc3)CC2)c1Cl
Structure:
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