Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50589714
Substrate
n/a
Meas. Tech.
ChEMBL_2194198 (CHEMBL5106558)
Ki
9.9±n/a nM
Citation
 Mishiro, K; Wang, M; Hirata, S; Fuchigami, T; Shiba, K; Kinuya, S; Ogawa, K Development of tumor-targeting aza-vesamicol derivatives with high affinity for sigma receptors for cancer theranostics. RSC Med Chem 13:986-997 (2022) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50589714
Synonyms:
CHEMBL5203770
Type:
Small organic molecule
Emp. Form.:
C17H25BrN2O
Mol. Mass.:
353.297
SMILES:
O[C@H]1CCC[C@@H]1N1CCN(CCc2ccc(Br)cc2)CC1 |r|
Structure:
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