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Target
Stimulator of interferon genes protein
Ligand
BDBM50509050
Substrate
n/a
Meas. Tech.
ChEMBL_2248029 (CHEMBL5162239)
EC50
<1.000000±n/a nM
Citation
 Jeon, MJ; Lee, H; Lee, J; Baek, SY; Lee, D; Jo, S; Lee, JY; Kang, M; Jung, HR; Han, SB; Kim, NJ; Lee, S; Kim, H Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor. J Med Chem 65:5407-5432 (2022) [PubMed] 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM50509050
Synonyms:
CHEMBL4438309
Type:
Small organic molecule
Emp. Form.:
C42H51N13O7
Mol. Mass.:
849.9372
SMILES:
CCn1nc(C)cc1C(=O)\N=c1/[nH]c2cc(cc(OC)c2n1C\C=C\Cn1c2c(OCCCN3CCOCC3)cc(cc2[nH]\c1=N/C(=O)c1cc(C)nn1CC)C(N)=O)C(N)=O
Structure:
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