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Target
Monocarboxylate transporter 1
Ligand
BDBM4350
Substrate
n/a
Meas. Tech.
ChEMBL_2261029 (CHEMBL5216040)
IC50
281±n/a nM
Citation
 Wang, Y; Qin, L; Chen, W; Chen, Q; Sun, J; Wang, G Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1. Eur J Med Chem 226:0 (2021) [PubMed] 
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1
Type:
Enzyme
Mol. Mass.:
53245.17
Organism:
Rattus norvegicus (Rat)
Description:
P53987
Residue:
494
Sequence:
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSSGDPAEEESPV
  
Inhibitor
Name:
BDBM4350
Synonyms:
(2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid | benzylidenemalononitrile (BMN) deriv. 34
Type:
Small organic molecule
Emp. Form.:
C10H7NO3
Mol. Mass.:
189.1675
SMILES:
OC(=O)C(=C\c1ccc(O)cc1)\C#N
Structure:
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