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Target
Monocarboxylate transporter 4
Ligand
BDBM50606665
Substrate
n/a
Meas. Tech.
ChEMBL_2261032 (CHEMBL5216043)
IC50
1.000000±n/a nM
Citation
 Wang, Y; Qin, L; Chen, W; Chen, Q; Sun, J; Wang, G Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1. Eur J Med Chem 226:0 (2021) [PubMed] 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM50606665
Synonyms:
Isotense | Londomin | NSC-77030 | Neoreserpan | SU 3118 | SU-3118 | SYROSINGOPINE | Siringina | Syrosingopine
Type:
Small organic molecule
Emp. Form.:
C35H42N2O11
Mol. Mass.:
666.7148
SMILES:
[H][C@]12C[C@@H](OC(=O)c3cc(OC)c(OC(=O)OCC)c(OC)c3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]1([H])N(CCc3c1[nH]c1cc(OC)ccc31)C2
Structure:
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