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Target
Ribosomal protein S6 kinase beta-1/beta-2
Ligand
BDBM50196392
Substrate
n/a
Meas. Tech.
ChEMBL_420106 (CHEMBL873748)
IC50
1000±n/a nM
Citation
 El Abdellaoui, H; Varaprasad, CV; Barawkar, D; Chakravarty, S; Maderna, A; Tam, R; Chen, H; Allan, M; Wu, JZ; Appleby, T; Yan, S; Zhang, W; Lang, S; Yao, N; Hamatake, R; Hong, Z Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett 16:5561-6 (2006) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase beta-1/beta-2
Synonyms:
Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase 1/2 | Ribosomal protein S6 kinase 2/S6K1
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 195569
Components:
This complex has 2 components.
Component 1
Name:
Ribosomal protein S6 kinase beta-1
Synonyms:
70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1
Type:
Enzyme
Mol. Mass.:
59139.89
Organism:
Homo sapiens (Human)
Description:
His-tagged S6K1.
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Component 2
Name:
Ribosomal protein S6 kinase beta-2
Synonyms:
KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B
Type:
PROTEIN
Mol. Mass.:
53460.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306115
Residue:
482
Sequence:
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR
  
Component 3
Name:
Ribosomal protein S6 kinase beta-2
Synonyms:
KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B
Type:
PROTEIN
Mol. Mass.:
53460.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306115
Residue:
482
Sequence:
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR
  
Inhibitor
Name:
BDBM50196392
Synonyms:
3-hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidine | 3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenylamino)phenylamino)isothiazole-4-carboximidamide | CHEMBL253116
Type:
Small organic molecule
Emp. Form.:
C19H21N5O2S
Mol. Mass.:
383.467
SMILES:
CC(CO)N=C(N)c1c(Nc2ccc(Nc3ccccc3)cc2)s[nH]c1=O |w:4.3|
Structure:
Search PDB for entries with ligand similarity: