Reaction Details Report a problem with these data
Target
Furin
Ligand
BDBM50279609
Substrate
n/a
Meas. Tech.
ChEMBL_522272 (CHEMBL998935)
Ki
1768±n/a nM
Citation
Worachartcheewan, A; Nantasenamat, C; Naenna, T; Isarankura-Na-Ayudhya, C; Prachayasittikul, V Modeling the activity of furin inhibitors using artificial neural network. Eur J Med Chem 44:1664-73 (2009) [PubMed] Article
More Info.:
Target
Name:
Furin
Synonyms:
FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86676.01
Organism:
Homo sapiens (Human)
Description:
P09958
Residue:
794
Sequence:
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
Inhibitor
Name:
BDBM50279609
Synonyms:
(1S,2S,4R,5R)-2,4-dicarbamimidamido-5-{[(3-carbamimidamidophenyl)carbamoyl]oxy}cyclohexyl N-(3-carbamimidamidophenyl)carbamate | CHEMBL506831
Type:
Small organic molecule
Emp. Form.:
C24H34N14O4
Mol. Mass.:
582.6182
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6@@H]-1-[#6]-[#6@H](\[#7]=[#6](/[#7])-[#7])-[#6@H](-[#6]-[#6@H]1-[#8]-[#6](=O)-[#7]-c1cccc(c1)\[#7]=[#6](\[#7])-[#7])-[#8]-[#6](=O)-[#7]-c1cccc(c1)\[#7]=[#6](\[#7])-[#7] |r|