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Target
Endothelin-converting enzyme 1
Ligand
BDBM50287859
Substrate
n/a
Meas. Tech.
ChEBML_64372
IC50
400±n/a nM
Citation
 Deprez, P; Guillaume, J; Dumas, J; Vevert, JP Thiol inhibitors of endothelin-converting enzyme Bioorg Med Chem Lett 6:2317-2322 (1996)    Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE)
Type:
Protein
Mol. Mass.:
86126.89
Organism:
Rattus norvegicus (Rat)
Description:
P42893
Residue:
762
Sequence:
MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
  
Inhibitor
Name:
BDBM50287859
Synonyms:
(S)-3-(1H-Indol-3-yl)-2-((R)-2-mercapto-3-phenyl-propionylamino)-propionic acid | CHEMBL75520
Type:
Small organic molecule
Emp. Form.:
C20H20N2O3S
Mol. Mass.:
368.449
SMILES:
OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](S)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: