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Target
Bcl-2-like protein 1
Ligand
BDBM50293170
Substrate
n/a
Meas. Tech.
ChEMBL_496943 (CHEMBL1002038)
Kd
1.08E7±n/a nM
Citation
 Janssen, CO; Lim, S; Lo, EP; Wan, KF; Yu, VC; Lee, MA; Ng, SB; Everett, MJ; Buss, AD; Lane, DP; Boyce, RS Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. Bioorg Med Chem Lett 18:5771-3 (2009) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50293170
Synonyms:
(1R,12S,16S,19R,20R,21S,22R)-4,8,21-Trihydroxy-10-(S)-methyl-5,12,14,16,20,22-hexamethyl-23-oxa-tricyclo[17.3.1.0*2,7*]tricosa-2(7),4,14-triene-3,6,9-trione | CHEMBL499851
Type:
Small organic molecule
Emp. Form.:
C29H42O7
Mol. Mass.:
502.6396
SMILES:
C[C@@H]1[C@H](O)[C@@H](C)[C@H]2O[C@@H]1CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)C(=O)C(O)C1=C2C(=O)C(=O)C(C)C1=O |r,c:14,27|
Structure:
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