Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50332125
Substrate
n/a
Meas. Tech.
ChEMBL_687950 (CHEMBL1291622)
IC50
148±n/a nM
Citation
 Zhao, L; Zhang, Y; Dai, C; Guzi, T; Wiswell, D; Seghezzi, W; Parry, D; Fischmann, T; Siddiqui, MA Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors. Bioorg Med Chem Lett 20:7216-21 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50332125
Synonyms:
(R)-4-(3-aminopiperidin-1-yl)-2-(4-chlorophenyl)thieno[3,2-c]pyridine-7-carboxamide | CHEMBL1288248
Type:
Small organic molecule
Emp. Form.:
C19H19ClN4OS
Mol. Mass.:
386.898
SMILES:
N[C@@H]1CCCN(C1)c1ncc(C(N)=O)c2sc(cc12)-c1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: