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Target
Histamine H4 receptor
Ligand
BDBM50343838
Substrate
n/a
Meas. Tech.
ChEMBL_747647 (CHEMBL1777265)
Ki
155±n/a nM
Citation
 Wiecek, M; Kottke, T; Ligneau, X; Schunack, W; Seifert, R; Stark, H; Handzlik, J; Kiec-Kononowicz, K N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands. Bioorg Med Chem 19:2850-8 (2011) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50343838
Synonyms:
3-(1H-imidazol-4-yl)propyl 2-cyclopropylethylcarbamate maleate | CHEMBL1774598
Type:
Small organic molecule
Emp. Form.:
C12H19N3O2
Mol. Mass.:
237.2982
SMILES:
O=C(NCCC1CC1)OCCCc1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: