Reaction Details Report a problem with these data
Target
Sphingomyelin phosphodiesterase 2
Ligand
BDBM50128896
Substrate
n/a
Meas. Tech.
ChEBML_144315
IC50
8700±n/a nM
Citation
Taguchi, M; Sugimoto, K; Goda, K; Akama, T; Yamamoto, K; Suzuki, T; Tomishima, Y; Nishiguchi, M; Arai, K; Takahashi, K; Kobori, T Sphingomyelin analogues as inhibitors of sphingomyelinase. Bioorg Med Chem Lett 13:1963-6 (2003) [PubMed] Article
More Info.:
Target
Name:
Sphingomyelin phosphodiesterase 2
Synonyms:
NSMA_RAT | Neutral sphingomyelinase | Smpd2
Type:
PROTEIN
Mol. Mass.:
47651.22
Organism:
Rattus norvegicus
Description:
ChEMBL_611790
Residue:
422
Sequence:
MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLKQKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLNMHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYVLYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERSALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTPSVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAEEK
Inhibitor
Name:
BDBM50128896
Synonyms:
CHEMBL416323 | {2-[(E)-(2S,3R)-2-(2,2-Dimethyl-propionylamino)-3-hydroxy-octadec-4-enyloxycarbonylamino]-ethyl}-trimethyl-ammonium; iodide
Type:
Small organic molecule
Emp. Form.:
C29H58N3O4
Mol. Mass.:
512.788
SMILES:
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](COC(=O)NCC[N+](C)(C)C)NC(=O)C(C)(C)C