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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50054122
Substrate
n/a
Meas. Tech.
ChEMBL_1103 (CHEMBL616426)
Ki
66±n/a nM
Citation
 Berardi, F; Giudice, G; Perrone, R; Tortorella, V; Govoni, S; Lucchi, L Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives. J Med Chem 39:4255-60 (1996) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50054122
Synonyms:
2-[4-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-butyl]-1,2,3,4-tetrahydro-isoquinoline | CHEMBL337709
Type:
Small organic molecule
Emp. Form.:
C23H29N
Mol. Mass.:
319.4831
SMILES:
C(CCN1CCc2ccccc2C1)CC1CCCc2ccccc12
Structure:
Search PDB for entries with ligand similarity: