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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50140098
Substrate
n/a
Meas. Tech.
ChEMBL_71599 (CHEMBL689131)
Ki
4±n/a nM
Citation
 Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem 47:1259-71 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50140098
Synonyms:
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(S)-2-[(3-methyl-thiophen-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione | CHEMBL283381
Type:
Small organic molecule
Emp. Form.:
C28H28F3N3O3S
Mol. Mass.:
543.6
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2sccc2C)c1=O |wU:26.28,(9.6,-.48,;8.26,-1.28,;8.28,-2.84,;9.61,-3.59,;9.63,-5.13,;8.31,-5.91,;6.98,-5.14,;6.96,-3.6,;5.84,-2.49,;5.65,-5.92,;5.66,-7.46,;7,-8.23,;4.34,-8.24,;4.34,-9.77,;3,-10.56,;1.68,-9.77,;.58,-8.68,;.34,-10.56,;.34,-12.09,;1.69,-12.85,;3.01,-12.07,;4.1,-13.16,;2.99,-7.48,;1.66,-8.24,;2.99,-5.94,;1.66,-5.16,;1.66,-3.6,;3.01,-2.82,;.31,-2.84,;.31,-1.28,;-1.17,-.76,;-1.62,.73,;-3.18,.77,;-3.69,-.71,;-2.45,-1.64,;-2.45,-3.2,;4.31,-5.16,;4.3,-3.63,)|
Structure:
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