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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50140102
Substrate
n/a
Meas. Tech.
ChEMBL_71599 (CHEMBL689131)
Ki
25±n/a nM
Citation
 Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem 47:1259-71 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50140102
Synonyms:
3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL23729
Type:
Small organic molecule
Emp. Form.:
C29H28F3N3O3
Mol. Mass.:
523.5461
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2ccccc2)c1=O |wU:26.28,(4.84,1.97,;3.5,1.18,;3.51,-.38,;4.84,-1.13,;4.87,-2.67,;3.55,-3.44,;2.23,-2.67,;2.2,-1.16,;1.09,-.05,;.9,-3.45,;.9,-5,;2.24,-5.76,;-.42,-5.76,;-.42,-7.3,;-1.74,-8.07,;-3.07,-7.3,;-4.17,-6.2,;-4.4,-8.07,;-4.39,-9.61,;-3.04,-10.36,;-1.74,-9.6,;-.65,-10.67,;-1.76,-5.01,;-3.08,-5.76,;-1.76,-3.48,;-3.08,-2.71,;-3.08,-1.16,;-1.74,-.36,;-4.43,-.38,;-4.43,1.18,;-5.9,1.69,;-6.2,3.22,;-7.67,3.73,;-8.84,2.7,;-8.55,1.17,;-7.07,.68,;-.44,-2.7,;-.44,-1.16,)|
Structure:
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