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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50140097
Substrate
n/a
Meas. Tech.
ChEMBL_71599 (CHEMBL689131)
Ki
13±n/a nM
Citation
 Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem 47:1259-71 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50140097
Synonyms:
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(R)-2-[(thiazol-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione | CHEMBL280664
Type:
Small organic molecule
Emp. Form.:
C26H25F3N4O3S
Mol. Mass.:
530.562
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C)NCc2nccs2)c1=O |wD:26.28,(4.83,2.23,;3.49,1.44,;3.5,-.13,;4.84,-.88,;4.86,-2.42,;3.54,-3.2,;2.2,-2.44,;2.19,-.91,;1.07,.21,;.88,-3.22,;.88,-4.77,;2.23,-5.52,;-.44,-5.54,;-.44,-7.08,;-1.78,-7.86,;-3.1,-7.08,;-4.21,-5.97,;-4.44,-7.86,;-4.44,-9.4,;-3.09,-10.16,;-1.77,-9.38,;-.68,-10.47,;-1.79,-4.78,;-3.12,-5.55,;-1.79,-3.24,;-3.12,-2.47,;-3.12,-.91,;-1.77,-.13,;-4.47,-.13,;-4.47,1.44,;-5.96,1.94,;-7.24,1.06,;-8.47,2,;-7.97,3.47,;-6.41,3.45,;-.47,-2.46,;-.47,-.92,)|
Structure:
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