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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50140115
Substrate
n/a
Meas. Tech.
ChEMBL_71599 (CHEMBL689131)
Ki
7±n/a nM
Citation
 Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem 47:1259-71 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50140115
Synonyms:
1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-[(R)-1-methyl-2-(2-methyl-benzylamino)-ethyl]-1H-pyrimidine-2,4-dione | CHEMBL283170
Type:
Small organic molecule
Emp. Form.:
C30H30F3N3O3
Mol. Mass.:
537.5727
SMILES:
COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n([C@H](C)CNCc2ccccc2C)c1=O |wD:25.27,(8.37,1.48,;7.04,.68,;7.05,-.88,;8.38,-1.64,;8.41,-3.17,;7.08,-3.95,;5.76,-3.17,;5.74,-1.65,;4.37,-.87,;4.43,-3.95,;4.44,-5.5,;5.78,-6.26,;3.12,-6.26,;3.12,-7.79,;1.79,-8.57,;.47,-7.79,;-.63,-6.71,;-.86,-8.57,;-.86,-10.1,;.48,-10.86,;1.8,-10.1,;2.89,-11.18,;1.78,-5.5,;.46,-6.27,;1.78,-3.97,;.46,-3.21,;-.89,-3.99,;.46,-1.65,;-.9,-.88,;-.9,.68,;.46,1.46,;1.79,.68,;3.14,1.45,;3.14,3.01,;1.78,3.79,;.43,3.01,;-.91,3.79,;3.1,-3.19,;3.09,-1.66,)|
Structure:
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