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Target
Sterol 26-hydroxylase, mitochondrial
Ligand
BDBM50370925
Substrate
n/a
Meas. Tech.
ChEMBL_430507 (CHEMBL917756)
IC50
>1000±n/a nM
Citation
 Kahraman, M; Sinishtaj, S; Dolan, PM; Kensler, TW; Peleg, S; Saha, U; Chuang, SS; Bernstein, G; Korczak, B; Posner, GH Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3). J Med Chem 47:6854-63 (2004) [PubMed]  Article 
Target
Name:
Sterol 26-hydroxylase, mitochondrial
Synonyms:
CP27A_HUMAN | CYP27 | CYP27A1
Type:
PROTEIN
Mol. Mass.:
60250.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_430507
Residue:
531
Sequence:
MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC
  
Inhibitor
Name:
BDBM50370925
Synonyms:
CHEMBL1627233
Type:
Small organic molecule
Emp. Form.:
C29H41NO3S
Mol. Mass.:
483.706
SMILES:
C[C@H](CC=S(N)(=O)c1ccccc1)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r|
Structure:
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