Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391419
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
0.95±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391419
Synonyms:
CHEMBL2146510
Type:
Small organic molecule
Emp. Form.:
C24H35ClN4O2S2
Mol. Mass.:
511.143
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(Cl)cc1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:23.24,6.5,(-2.43,-4.55,;-2.41,-3.01,;-3.74,-2.23,;-3.73,-.69,;-2.39,.07,;-1.06,-.71,;.28,.05,;1.61,-.75,;2.94,.01,;2.97,1.55,;1.64,2.33,;.29,1.58,;4.31,2.3,;5.63,1.52,;6.39,.19,;4.86,.19,;6.98,2.27,;6.99,3.8,;8.34,4.55,;9.67,3.76,;11.02,4.51,;9.64,2.22,;8.29,1.47,;-4.99,.19,;-4.53,1.66,;-5.56,2.79,;-7.06,2.46,;-8.31,3.36,;-9.55,2.44,;-11.02,2.91,;-9.07,.98,;-7.52,.99,;-6.49,-.13,)|
Structure:
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