Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391424
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
0.78±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391424
Synonyms:
CHEMBL2146509
Type:
Small organic molecule
Emp. Form.:
C25H38N4O3S2
Mol. Mass.:
506.724
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(OC)cc1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:24.25,6.5,(-3.09,-4.55,;-3.07,-3.01,;-4.4,-2.23,;-4.39,-.69,;-3.05,.07,;-1.72,-.71,;-.38,.05,;.95,-.75,;2.28,.01,;2.3,1.55,;.98,2.33,;-.37,1.58,;3.65,2.3,;4.97,1.52,;5.73,.19,;4.19,.19,;6.31,2.27,;6.33,3.8,;7.67,4.55,;9,3.76,;10.35,4.51,;11.67,3.71,;8.98,2.21,;7.63,1.47,;-5.65,.19,;-5.19,1.66,;-6.22,2.79,;-7.71,2.46,;-8.97,3.36,;-10.2,2.44,;-11.67,2.91,;-9.73,.98,;-8.18,.99,;-7.15,-.13,)|
Structure:
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