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Target
Protein-serine O-palmitoleoyltransferase porcupine
Ligand
BDBM50428039
Substrate
n/a
Meas. Tech.
ChEMBL_941167 (CHEMBL2330993)
EC50
50±n/a nM
Citation
 Wang, X; Moon, J; Dodge, ME; Pan, X; Zhang, L; Hanson, JM; Tuladhar, R; Ma, Z; Shi, H; Williams, NS; Amatruda, JF; Carroll, TJ; Lum, L; Chen, C The development of highly potent inhibitors for porcupine. J Med Chem 56:2700-4 (2013) [PubMed]  Article 
Target
Name:
Protein-serine O-palmitoleoyltransferase porcupine
Synonyms:
PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC
Type:
PROTEIN
Mol. Mass.:
52528.36
Organism:
Mus musculus
Description:
ChEMBL_941167
Residue:
461
Sequence:
MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVRWLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVEVVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVEHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
  
Inhibitor
Name:
BDBM50428039
Synonyms:
CHEMBL2325511
Type:
Small organic molecule
Emp. Form.:
C22H17ClN4O3S3
Mol. Mass.:
517.043
SMILES:
COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(Cl)cc3s2)nc2CCSc2c1=O |(29.25,-7.08,;27.92,-7.85,;27.92,-9.39,;29.26,-10.16,;29.27,-11.7,;27.93,-12.48,;26.6,-11.71,;26.6,-10.17,;25.27,-9.4,;25.26,-7.85,;26.59,-7.07,;26.59,-5.53,;27.92,-4.75,;27.91,-3.21,;29.26,-5.52,;30.59,-4.74,;31.99,-5.37,;33.01,-4.22,;34.55,-4.21,;35.32,-2.88,;34.53,-1.55,;35.3,-.21,;33,-1.56,;32.24,-2.89,;30.74,-3.21,;23.92,-7.08,;22.59,-7.86,;21.12,-7.39,;20.22,-8.64,;21.13,-9.88,;22.59,-9.4,;23.93,-10.17,;23.93,-11.71,)|
Structure:
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