Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50431749
Substrate
n/a
Meas. Tech.
ChEMBL_951811 (CHEMBL2353001)
EC50
200±n/a nM
Citation
 Cheruvallath, ZS; Gwaltney, SL; Sabat, M; Tang, M; Feng, J; Wang, H; Miura, J; Guntupalli, P; Jennings, A; Hosfield, D; Lee, B; Wu, Y Design, synthesis and SAR of novel glucokinase activators. Bioorg Med Chem Lett 23:2166-71 (2013) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50431749
Synonyms:
CHEMBL2346879
Type:
Small organic molecule
Emp. Form.:
C22H26F2N4O4S2
Mol. Mass.:
512.593
SMILES:
Fc1cc(F)cc(c1)S(=O)(=O)N1CCN([C@@H](CC2CCCCC2)C(=O)Nc2nccs2)C(=O)C1 |r|
Structure:
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