Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50431765
Substrate
n/a
Meas. Tech.
ChEMBL_951811 (CHEMBL2353001)
EC50
1200±n/a nM
Citation
 Cheruvallath, ZS; Gwaltney, SL; Sabat, M; Tang, M; Feng, J; Wang, H; Miura, J; Guntupalli, P; Jennings, A; Hosfield, D; Lee, B; Wu, Y Design, synthesis and SAR of novel glucokinase activators. Bioorg Med Chem Lett 23:2166-71 (2013) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50431765
Synonyms:
CHEMBL2346894
Type:
Small organic molecule
Emp. Form.:
C23H24ClN5O4S
Mol. Mass.:
501.986
SMILES:
Clc1cnc(NC(=O)C(CC2CCCCO2)n2cnc3cc(ccc3c2=O)C(=O)NC2CC2)s1
Structure:
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