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Target
Tyrosine-protein kinase SYK
Ligand
BDBM122148
Substrate
n/a
Meas. Tech.
Mobility-Shift kinase assay
IC50
5.61±n/a nM
Citation
 Che, J; Ding, Q; He, X; Liu, H; Liu, Y; Michellys, P; Okram, B; Wu, X; Yang, K; Zhu, X Compounds and compositions as Syk kinase inhibitors US Patent  US8722692 Publication Date 5/13/2014 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM122148
Synonyms:
US8722692, 588
Type:
Small organic molecule
Emp. Form.:
C26H34N6O2
Mol. Mass.:
462.5872
SMILES:
Cn1cnc2cc(nc(N[C@@H]3CC[C@H](N)CC3)c2c1=O)-c1ccc(cc1)N1CCC(C)(O)CC1 |r,wD:10.9,13.13,(8.11,-1.82,;6.77,-1.05,;6.77,.49,;5.44,1.26,;4.1,.49,;2.77,1.26,;1.44,.49,;1.44,-1.05,;2.77,-1.82,;2.77,-3.36,;1.44,-4.13,;1.44,-5.67,;.1,-6.44,;-1.23,-5.67,;-2.56,-6.44,;-1.23,-4.13,;.1,-3.36,;4.1,-1.05,;5.44,-1.82,;5.44,-3.36,;.1,1.26,;.1,2.8,;-1.23,3.57,;-2.56,2.8,;-2.56,1.26,;-1.23,.49,;-3.9,3.57,;-3.9,5.11,;-5.23,5.88,;-6.57,5.11,;-7.34,6.44,;-8.11,5.11,;-6.57,3.57,;-5.23,2.8,)|
Structure:
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