Reaction Details Report a problem with these data
Target
Rho-associated protein kinase 2 [1-552]
Ligand
BDBM50196697
Substrate
n/a
Meas. Tech.
FRET-Based Enzyme-Coupled Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
5500±3100 nM
Comments
extracted
Citation
 Schonbrunn, E; Li, R; Sebti, SM Inhibitors of rho associated protein kinases (ROCK) and methods of use US Patent  US9409868 Publication Date 8/9/2016 
Target
Name:
Rho-associated protein kinase 2 [1-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme
Mol. Mass.:
63353.50
Organism:
Homo sapiens (Human)
Description:
aa 1-552
Residue:
552
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM50196697
Synonyms:
1-benzyl-3-(1H-indazol-5-yl)urea | CHEMBL225282 | N-benzyl-N0-(1H-5-indazolyl)urea | US9409868, 12
Type:
Small organic molecule
Emp. Form.:
C15H14N4O
Mol. Mass.:
266.2979
SMILES:
O=C(NCc1ccccc1)Nc1ccc2[nH]ncc2c1
Structure:
Search PDB for entries with ligand similarity: