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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM257529
Substrate
n/a
Meas. Tech.
PPlase Assay
Ki
10±1.1 nM
Citation
 Gregory, MA; Kendrew, SG; Moss, SJ; Wilkinson, B Rapamycin analogues and their pharmaceutical use US Patent  US9505773 Publication Date 11/29/2016 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM257529
Synonyms:
US9505773, Meridamycin
Type:
Small organic molecule
Emp. Form.:
C45H73NO12
Mol. Mass.:
820.0606
SMILES:
[H]C12CCC(C)C(O)(O1)C(=O)C(=O)N1CCCCC1C(=O)OC(C\C=C(CC)/C(O)C(C)CC(C)\C=C(C)/C(O)CC(O)CC(O)C(C)C(O)C2)C(\C)=C\C(C)C(C)=O |t:26,37|
Structure:
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