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Target
Bromodomain-containing protein 4 [44-164]
Ligand
BDBM425307
Substrate
n/a
Meas. Tech.
Alphascreen Binding Assay
IC50
<1000±n/a nM
Citation
 Zhang, J; Buell, J; Chan, K; Ibrahim, PN; Lin, J; Pham, P; Shi, S; Spevak, W; Wu, G; Wu, J Heterocyclic compounds and uses thereof US Patent  US10519177 Publication Date 12/31/2019 
Target
Name:
Bromodomain-containing protein 4 [44-164]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (aa 44-164) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14412.06
Organism:
Homo sapiens (Human)
Description:
BRD4-BD1 (44-164)
Residue:
121
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
  
Inhibitor
Name:
BDBM425307
Synonyms:
US10519177, Compound P-0186 | ethyl 2-[6-(3,5-dimethylisoxazol-4-yl)-3-(1- methylpyrazol-4-yl)pyrrolo[3,2-b]pyridin-1- yl]-2-phenyl-acetate
Type:
Small organic molecule
Emp. Form.:
C26H25N5O3
Mol. Mass.:
455.5084
SMILES:
CCOC(=O)C(c1ccccc1)n1cc(-c2cnn(C)c2)c2ncc(cc12)-c1c(C)noc1C
Structure:
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