Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 4
Ligand
BDBM444608
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
1.45±n/a nM
Citation
 Xia, G; Wang, Q; Shi, C; Zhai, X; Ge, H; Liao, X; Mao, Y; Xiang, Z; Han, Y; Huo, G; Liu, Y Substituted pyrimidines as cyclin-dependent kinase inhibitors US Patent  US10988476 Publication Date 4/27/2021 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM444608
Synonyms:
US10662186, Compound 155 | US10988476, Compound I-155
Type:
Small organic molecule
Emp. Form.:
C31H39F2N8OP
Mol. Mass.:
608.6649
SMILES:
Cc1nc2c(F)cc(cc2n1C(C)(C)C)-c1nc(Nc2ccc3CN(CCN4CCP(C)(=O)CC4)CCc3n2)ncc1F
Structure:
Search PDB for entries with ligand similarity: