Reaction Details Report a problem with these data
Target
Wee1-like protein kinase
Ligand
BDBM549213
Substrate
n/a
Meas. Tech.
LanthaScreen TR-FRET Assay
IC50
0.600±n/a nM
Citation
 Chakravarty, S; Pham, SM; Kankanala, J; Agarwal, AK; Pujala, B; Soni, S; Arya, SK; Palve, D; Gupta, A; Kumar, V Heterocyclic compounds and uses thereof US Patent  US11299493 Publication Date 4/12/2022 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM549213
Synonyms:
US11299493, Compound 1.131 | US11299493, S-33
Type:
Small organic molecule
Emp. Form.:
C25H29N7O
Mol. Mass.:
443.5441
SMILES:
CCn1n(-c2cccc(n2)C(C)(C)C)c2nc(Nc3ccc4CNCCc4c3)ncc2c1=O
Structure:
Search PDB for entries with ligand similarity: