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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50240692
Substrate
n/a
Meas. Tech.
ChEMBL_1712853 (CHEMBL4122902)
EC50
<100±n/a nM
Citation
 Bertron, JL; Cho, HP; Garcia-Barrantes, PM; Panarese, JD; Salovich, JM; Nance, KD; Engers, DW; Rook, JM; Blobaum, AL; Niswender, CM; Stauffer, SR; Conn, PJ; Lindsley, CW The discovery of VU0486846: steep SAR from a series of M Bioorg Med Chem Lett 28:2175-2179 (2018) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50240692
Synonyms:
CHEMBL4078588
Type:
Small organic molecule
Emp. Form.:
C25H25N3O2
Mol. Mass.:
399.4849
SMILES:
Cc1ccc(Cc2cc3c(ncn([C@H]4CCCC[C@@H]4O)c3=O)c3ccccc23)cn1 |r|
Structure:
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