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Target
Beta-glucuronidase
Ligand
BDBM50372514
Substrate
n/a
Meas. Tech.
ChEMBL_1718453 (CHEMBL4133453)
IC50
31300±n/a nM
Citation
 Bano, B; Arshia, na; Khan, KM; Kanwal, na; Fatima, B; Taha, M; Ismail, NH; Wadood, A; Ghufran, M; Perveen, S Synthesis, in vitro ?-glucuronidase inhibitory potential and molecular docking studies of quinolines. Eur J Med Chem 139:849-864 (2017) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB
Type:
Protein
Mol. Mass.:
74467.69
Organism:
Bos taurus (Bovine)
Description:
EC 3.2.1.31, bovine liver
Residue:
652
Sequence:
MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGFEQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRVVLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHTLPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQDIGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYLYSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSNVSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVTFVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSEYGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVRMIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
  
Inhibitor
Name:
BDBM50372514
Synonyms:
CHEMBL540966
Type:
Small organic molecule
Emp. Form.:
C15H11N3O4S
Mol. Mass.:
329.331
SMILES:
[O-][N+](=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2cccnc12
Structure:
Search PDB for entries with ligand similarity: