Reaction Details Report a problem with these data
Target
Cytoplasmic tyrosine-protein kinase BMX
Ligand
BDBM202197
Substrate
n/a
Meas. Tech.
ChEMBL_1743747 (CHEMBL4178257)
IC50
4682±n/a nM
Citation
Thakkar, M; Bhuniya, D; Kaduskar, R; Mengawade, T; Naik, K; Salunkhe, V; Bhalerao, A; Kurhade, S; Mavinahalli, J; Jain, V; Petla, R; Avaragolla, S; Ray, S; Rouduri, S; Dhanave, A; De, S; Pathade, V; Tambe, A; Raje, AA; Madgula, V; Joshi, S; Nadeem, A; Bala, M; Umrani, D; Hariharan, N; Kulkarni, B; Mookhtiar, KA Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett 27:1867-1873 (2017) [PubMed] Article
More Info.:
Target
Name:
Cytoplasmic tyrosine-protein kinase BMX
Synonyms:
BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK
Type:
Tyrosine-protein kinase
Mol. Mass.:
78030.42
Organism:
Homo sapiens (Human)
Description:
P51813
Residue:
675
Sequence:
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH