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Target
Carbonic anhydrase 4
Ligand
BDBM50503810
Substrate
n/a
Meas. Tech.
ChEMBL_1812136 (CHEMBL4311596)
Kd
810±n/a nM
Citation
 Va?kevi?ien?, I; Paketuryt?, V; Pajanok, N; ?ukauskas, ?; Sapijanskait?, B; Kantminien?, K; Mickevi?ius, V; Zubrien?, A; Matulis, D Pyrrolidinone-bearing methylated and halogenated benzenesulfonamides as inhibitors of carbonic anhydrases. Bioorg Med Chem 27:322-337 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50503810
Synonyms:
CHEMBL4462447
Type:
Small organic molecule
Emp. Form.:
C17H16BrN3O4S
Mol. Mass.:
438.296
SMILES:
NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2cccc(Br)c2)cc1
Structure:
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