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Target
Macrophage metalloelastase
Ligand
BDBM50299051
Substrate
n/a
Meas. Tech.
ChEMBL_1904575 (CHEMBL4406933)
IC50
200±n/a nM
Citation
 Ti, H; Zhou, Y; Liang, X; Li, R; Ding, K; Zhao, X Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem 62:5944-5978 (2019) [PubMed]  Article 
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM50299051
Synonyms:
CHEMBL573715 | N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfonyl]-phenyl}acetamide
Type:
Small organic molecule
Emp. Form.:
C21H19NO6S
Mol. Mass.:
413.444
SMILES:
COc1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2CC(=O)NO)cc1
Structure:
Search PDB for entries with ligand similarity: