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Target
6-pyruvoyl tetrahydrobiopterin synthase
Ligand
BDBM50544427
Substrate
n/a
Meas. Tech.
ChEMBL_1992578 (CHEMBL4626313)
IC50
>50000±n/a nM
Citation
 Ruddraraju, KV; Aggarwal, D; Niu, C; Baker, EA; Zhang, RY; Wu, L; Zhang, ZY Highly Potent and Selective  J Med Chem 63:9212-9227 (2020) [PubMed]  Article 
Target
Name:
6-pyruvoyl tetrahydrobiopterin synthase
Synonyms:
4.2.3.12 | 6-pyruvoyl tetrahydrobiopterin synthase | PTP synthase | PTPS | PTPS_HUMAN | PTS
Type:
PROTEIN
Mol. Mass.:
16386.01
Organism:
Homo sapiens
Description:
ChEMBL_119916
Residue:
145
Sequence:
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE
  
Inhibitor
Name:
BDBM50544427
Synonyms:
CHEMBL4632818 | US11192850, Entry 4g
Type:
Small organic molecule
Emp. Form.:
C19H16N2O6
Mol. Mass.:
368.3401
SMILES:
CN(C)c1cc(O)c(cc1C#Cc1cccc(NC(=O)C(O)=O)c1)C(O)=O
Structure:
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