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Target
Glutamate carboxypeptidase 2
Ligand
BDBM50106562
Substrate
n/a
Meas. Tech.
ChEMBL_141138 (CHEMBL749038)
IC50
199±n/a nM
Citation
 Jackson, PF; Tays, KL; Maclin, KM; Ko, YS; Li, W; Vitharana, D; Tsukamoto, T; Stoermer, D; Lu, XC; Wozniak, K; Slusher, BS Design and pharmacological activity of phosphinic acid based NAALADase inhibitors. J Med Chem 44:4170-5 (2001) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1
Type:
PROTEIN
Mol. Mass.:
84547.28
Organism:
Rattus norvegicus
Description:
ChEMBL_68365
Residue:
752
Sequence:
MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
  
Inhibitor
Name:
BDBM50106562
Synonyms:
4-Phenyl-2-phosphonomethyl-butyric acid | CHEMBL134087
Type:
Small organic molecule
Emp. Form.:
C11H15O5P
Mol. Mass.:
258.2076
SMILES:
OC(=O)C(CCc1ccccc1)CP(O)(O)=O
Structure:
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