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Target
Stromelysin-1
Ligand
BDBM50129020
Substrate
n/a
Meas. Tech.
ChEBML_104871
Ki
70±n/a nM
Citation
 Sawa, M; Kurokawa, K; Inoue, Y; Kondo, H; Yoshino, K Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). Bioorg Med Chem Lett 13:2021-4 (2003) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50129020
Synonyms:
CHEMBL59692 | ethyl N-{(1R)-1-[(hydroxyamino)carbonyl]-3-methylbutyl}-P-(4-methoxyphenyl)phosphonamidoate
Type:
Small organic molecule
Emp. Form.:
C15H25N2O5P
Mol. Mass.:
344.3432
SMILES:
CCOP(=O)(N[C@H](CC(C)C)C(=O)NO)c1ccc(OC)cc1
Structure:
Search PDB for entries with ligand similarity: