Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50064947
Substrate
n/a
Meas. Tech.
ChEMBL_2204123 (CHEMBL5116831)
Ki
3.9±n/a nM
Citation
 Levoin, N; Murthy, AVR; Narendar, V; Kumar, NS; Aparna, P; Bhavani, AKD; Reddy, CR; Mosset, P; Grée, R Discovery of potent dual ligands for dopamine D4 and ?1 receptors. Bioorg Med Chem 69:0 (2022) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50064947
Synonyms:
CHEMBL76895 | N-(1-Benzyl-piperidin-4-yl)-2-phenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C20H24N2O
Mol. Mass.:
308.4174
SMILES:
O=C(Cc1ccccc1)NC1CCN(Cc2ccccc2)CC1
Structure:
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