Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50177871
Substrate
n/a
Meas. Tech.
ChEMBL_326511 (CHEMBL864539)
IC50
>10000±n/a nM
Citation
 Martín-Martínez, M; De la Figuera, N; Latorre, M; García-López, MT; Cenarruzabeitia, E; Del Río, J; González-Muñiz, R Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics. J Med Chem 48:7667-74 (2005) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin B receptor | Cholecystokinin receptor | GASR_RAT | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48980.43
Organism:
RAT
Description:
Cholecystokinin A CCKBR RAT::P30553
Residue:
452
Sequence:
MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50177871
Synonyms:
(3S,6S,9R,1'R)-3-[Nalpha-(tert-butoxycarbonyl)-D-tryptophyl)amino]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane | CHEMBL436123
Type:
Small organic molecule
Emp. Form.:
C33H40N6O6S
Mol. Mass.:
648.772
SMILES:
CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CC[C@@H]2SC[C@H](N2C1=O)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Structure:
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