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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50605690
Substrate
n/a
Meas. Tech.
ChEMBL_2252661 (CHEMBL5166871)
IC50
>10000±n/a nM
Citation
 Bononi, G; Di Stefano, M; Poli, G; Ortore, G; Meier, P; Masetto, F; Caligiuri, I; Rizzolio, F; Macchia, M; Chicca, A; Avan, A; Giovannetti, E; Vagaggini, C; Brai, A; Dreassi, E; Valoti, M; Minutolo, F; Granchi, C; Gertsch, J; Tuccinardi, T Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives. J Med Chem 65:7118-7140 (2022) [PubMed] 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM50605690
Synonyms:
CHEMBL5180084
Type:
Small organic molecule
Emp. Form.:
C25H23F3N2O3
Mol. Mass.:
456.4569
SMILES:
Oc1cccc(c1)C(=O)N1CCC(Cc2cccc(Oc3ncccc3C(F)(F)F)c2)CC1
Structure:
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