Reaction Details Report a problem with these data
Target
Sphingomyelinase C
Ligand
BDBM248057
Substrate
n/a
Meas. Tech.
ChEMBL_2266750
Ki
5200±n/a nM
Citation
 Skácel, J; Slusher, BS; Tsukamoto, T Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network. J Med Chem 64:279-297 (2021) [PubMed] 
Target
Name:
Sphingomyelinase C
Synonyms:
PHL2_BACCE | Sphingomyelinase (SMase) | sph
Type:
Enzyme
Mol. Mass.:
36871.19
Organism:
Bacillus cereus
Description:
P11889
Residue:
333
Sequence:
MKGKLLKGVLSLGVGLGALYSGTSAQAEASTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENNNDSEYASMFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFQKYTYNDYSDDYPVEATISMK
  
Inhibitor
Name:
BDBM248057
Synonyms:
RY221B-a
Type:
Small organic molecule
Emp. Form.:
C35H55N3O3
Mol. Mass.:
565.8295
SMILES:
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](COCc1cccc(n1)-c1ccccn1)NC(=O)CCCCC |r|
Structure:
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